A new beta release of our virtual appliance, CloVR beta-0.4, is available for download. Highlights from the release include, automated scaling of cluster instances for 454 and Illumina assembly and annotation pipelines (clovrMicrobe), clovrMetagenomics, and BLAST (clovrSearch), updated pipelines, documentation, SOPs and walkthroughs, improved support for VirtualBox, improved test suite, and numerous bug fixes. A screencast of an example pipeline is also available.